5-Bromo-2-pyrimidinecarboxylic acid(CAS: 37131-87-6)

5-Bromo-2-pyrimidinecarboxylic acid is a white crystalline powder with a molecular weight of 228.04 g/mol. It is sparingly soluble in water and ethanol. This compound exhibits moderate acidity and can undergo nucleophilic substitution reactions. It is also susceptible to hydrolysis under basic conditions.

5-Bromo-2-pyrimidinecarboxylic acid is typically synthesized by bromination of 2-pyrimidinecarboxylic acid. The reaction involves the use of bromine in the presence of a Lewis acid, such as aluminum bromide, to provide a bromo derivative. This method ensures high yield and selectivity.

5-Bromo-2-pyrimidinecarboxylic acid finds applications in the pharmaceutical industry for the synthesis of bioactive compounds, particularly in developing antiviral and anticancer drugs. It is also used in the polymer industry for the modification of polymers and in the semiconductor industry for the production of photolithographic resists.

When handling 5-Bromo-2-pyrimidinecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbent materials. For detailed safety information, refer to the Safety Data Sheet (SDS).