2-Bromo-4-(trifluoromethyl)phenol(CAS: 81107-97-3)

2-Bromo-4-(trifluoromethyl)phenol is a white crystalline solid with a molecular weight of approximately 257.03 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with nucleophiles under certain conditions. It has a pKa of approximately 7.5 and is a strong electron-withdrawing compound due to the trifluoromethyl group.

2-Bromo-4-(trifluoromethyl)phenol is typically synthesized by bromination of 4-(trifluoromethyl)phenol using a Br2/SO3/H2SO4 mixture. The reaction is conducted under anhydrous conditions to ensure high purity. The yield is usually around 80-90%, with good selectivity towards the brominated product.

2-Bromo-4-(trifluoromethyl)phenol is used in the pharmaceutical industry for the synthesis of certain drug intermediates and in the organic synthesis of novel compounds. It is also used in the polymer industry for the development of high-performance polymers and in the electronics industry for manufacturing semiconductors and sensors.

When handling 2-Bromo-4-(trifluoromethyl)phenol, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources and oxidizing agents. In case of a spill, it should be handled in a fume hood using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.