Methyl 3-(4-morpholinylmethyl)benzoate(CAS: 190660-95-8)

Methyl 3-(4-morpholinylmethyl)benzoate is a white to off-white crystalline solid with a molecular weight of approximately 268.39 g/mol. It is soluble in organic solvents like ethanol and methanol but less so in water. Chemically, it is relatively stable but can undergo hydrolysis under basic conditions. It has a pKa of about 7.5 and can form hydrogen bonds, which contribute to its crystalline structure and solubility properties.

Methyl 3-(4-morpholinylmethyl)benzoate is synthesized via the reaction of 4-morpholinylmethylbenzyl chloride with methyl alcohol. This reaction is typically conducted in the presence of a strong base like sodium hydroxide to facilitate the nucleophilic substitution. The product is isolated by extraction and purification using column chromatography. The yield is moderate, around 70-80%, and the method is known for its high selectivity.

Methyl 3-(4-morpholinylmethyl)benzoate is primarily used in the pharmaceutical industry as a precursor in the synthesis of various drugs. It is also utilized in the polymer industry for improving the thermal stability and solubility of polymers. Additionally, it has applications in sensors and semiconductors due to its optical and electronic properties.

When handling Methyl 3-(4-morpholinylmethyl)benzoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight and heat sources. Use a fume hood during handling to minimize inhalation risks. In case of a spill, sweep up the spill carefully and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.