N-(2-{2-Methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethyl)acetamide(CAS: 149456-97-3)

N-(2-{2-Methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethyl)acetamide is a crystalline compound with a molecular weight of approximately 532.67 g/mol. It has a low water solubility and is soluble in organic solvents like DMSO and acetonitrile. The compound exhibits good stability under normal conditions and is mildly reactive towards nucleophiles. It is typically stored at room temperature in a sealed container to prevent degradation.

N-(2-{2-Methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethyl)acetamide is synthesized via a multi-step process, involving the protection of the phenol group, coupling with an amino acid derivative, followed by acetylation and desilylation. The synthesis typically requires mild base catalysis and high-yielding conditions. Common solvents include THF and DMF.

N-(2-{2-Methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethyl)acetamide is primarily used in the pharmaceutical industry, where it serves as an intermediate in the synthesis of active pharmaceutical ingredients. It is also explored in the polymer industry for its potential as a functional monomer. Additionally, its unique structure makes it interesting for research in sensor technology and semiconductor applications.

When handling N-(2-{2-Methoxy-4-[(methylsulfonyl)amino]-5-phenoxyphenyl}-2-oxoethyl)acetamide, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.