1-(1,3-Benzoxazol-2-yl)ethanone(CAS: 122433-29-8)

1-(1,3-Benzoxazol-2-yl)ethanone is a white or off-white crystalline solid. The molecular weight is approximately 198.22 g/mol. It is slightly soluble in water but more soluble in common organic solvents like ethanol and acetone. Chemically, it is less reactive towards common reagents but shows good reactivity in certain functional group transformations.

1-(1,3-Benzoxazol-2-yl)ethanone can be synthesized via a condensation reaction between 2-bromobenzoxazole and ethanoyl chloride in the presence of a base like triethylamine. The reaction is typically carried out in an organic solvent such as dichloromethane. The yield is generally around 70-80%, and the product is purified by recrystallization from ethanol.

1-(1,3-Benzoxazol-2-yl)ethanone is primarily used in the pharmaceutical industry for the synthesis of certain drug candidates. It also finds applications in the polymer industry as a monomer or intermediate, and in the sensor industry for its sensing properties towards specific analytes.

When handling 1-(1,3-Benzoxazol-2-yl)ethanone, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be cleaned up using appropriate absorbent materials. Should exposure occur, seek medical attention immediately. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.