1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine(CAS: 852227-90-8)

1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine is a white crystalline solid with a molecular weight of approximately 348.39 g/mol. It has low solubility in water but is soluble in organic solvents such as THF and DMSO. This compound exhibits moderate reactivity, particularly towards nucleophiles and can be utilized in various chemical transformations. It is stable under normal conditions and is not typically hazardous in its pure form.

1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine is typically synthesized via a multistep process involving the formation of a boronic acid derivative, followed by its coupling with pyrrolidine. Common catalysts include palladium(II) acetate and cuprates. The synthesis generally provides good yields (up to 85%) and high selectivity, making it suitable for medicinal chemistry and material science applications.

1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine finds applications in pharmaceuticals, where it serves as a key intermediate in the synthesis of drug molecules. It is also used in the preparation of polymers and in sensor technology due to its unique chemical properties. Additionally, it can be utilized in the development of semiconductor materials, making it a versatile compound across multiple industries.

When handling 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine, it is advisable to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, ensure proper cleanup procedures are followed, and the spill area is thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.