5-Bromo-4-methoxy-2-(methylsulfanyl)pyrimidine(CAS: 81560-09-0)

5-Bromo-4-methoxy-2-(methylsulfanyl)pyrimidine is a colorless crystalline solid with a molecular weight of approximately 244.07 g/mol. It has a solubility of about 2.5 g/L in water and is moderately soluble in organic solvents. It is relatively inert under normal conditions but can react with strong oxidizing agents. This compound is typically used in the synthesis of other organic compounds and pharmaceuticals.

5-Bromo-4-methoxy-2-(methylsulfanyl)pyrimidine is commonly synthesized through the bromination of 4-methoxy-2-(methylsulfanyl)pyrimidine. This process involves the use of a brominating agent, such as N-bromosuccinimide (NBS) and azobisisobutyronitrile (AIBN) as a photoinitiator. The reaction typically yields a mixture of isomers, and purification is achieved through recrystallization or chromatography.

5-Bromo-4-methoxy-2-(methylsulfanyl)pyrimidine is widely used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the preparation of functionalized polymers and in the sensor industry for the development of chemical sensors. Additionally, it has potential uses in the semiconductor industry for electronic applications.

When handling 5-Bromo-4-methoxy-2-(methylsulfanyl)pyrimidine, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a laboratory coat. It should be stored in a cool, dry place away from direct sunlight and oxidizing agents. In case of a spill, it should be handled in a fume hood, and the Material Safety Data Sheet (MSDS) should be consulted for specific spill cleanup procedures. Always ensure good ventilation and work in a well-ventilated area or fume hood.