5-Chloro-2-methoxy-4-pyridinol(CAS: 1196146-71-0)

5-Chloro-2-methoxy-4-pyridinol is a white or off-white crystalline solid with a molecular weight of approximately 189.62 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases. It has a characteristic aromatic smell and is used in various applications due to its functional groups.

5-Chloro-2-methoxy-4-pyridinol can be synthesized through the reaction of 2-methoxy-4-pyridone with chlorine in the presence of an appropriate base. The reaction yields the desired product with good selectivity and high yield. Common solvents used include dimethylformamide (DMF) or acetonitrile, and the reaction is typically performed under mild heating conditions.

5-Chloro-2-methoxy-4-pyridinol is utilized in the pharmaceutical industry for the synthesis of certain drug molecules. It is also used in the polymer industry as a stabilizer and in the production of functional polymers. Additionally, it finds applications in the sensor and semiconductor industries for its unique chemical properties.

Handling 5-Chloro-2-methoxy-4-pyridinol requires appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.