1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea(CAS: 871700-18-4)

1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea (CAS: 871700-18-4) is a crystalline solid with a molecular weight of approximately 356.15 g/mol. It has a relatively low solubility in water but is soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound is known for its reactivity towards nucleophiles and its ability to undergo substitution reactions. It is also stable under normal conditions but requires handling in a fume hood to avoid inhalation of fumes.

1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea (CAS: 871700-18-4) can be synthesized via a multi-step process, typically involving the coupling of a fluoro-iodoarene with an amino-cyclopropyl urea derivative. The reaction is catalyzed by a palladium complex and proceeds under mild conditions. The yield is generally good, and the product is isolated by column chromatography. This synthesis is highly selective and produces the desired product with high purity.

1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea (CAS: 871700-18-4) is primarily used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It also has applications in the polymer industry, where it can be used as a catalyst or monomer. Additionally, it may be explored for its use in sensor development due to its reactivity and stability under certain conditions.

When handling 1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)urea (CAS: 871700-18-4), it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly washed down. The Safety Data Sheet (SDS) should be consulted for detailed information on handling and storage.