7-Chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine(CAS: 885461-50-7)

7-Chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is a crystalline solid with a molecular weight of approximately 305.03 g/mol. It has a low water solubility and is moderately soluble in common organic solvents like DMSO and DMF. This compound exhibits good thermal stability but is reactive towards nucleophiles and can undergo substitution reactions.

7-Chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is typically synthesized via a multistep process involving the condensation of 5-chloro-2-(trifluoromethyl)pyrimidin-4-amine with 1-methyl-1H-tetrazole-5-thiol. The reaction proceeds under basic conditions using sodium hydroxide, with good yield and selectivity.

7-Chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is primarily used in the pharmaceutical industry for the development of antiviral drugs. It is also explored in the polymer industry for its potential in material science applications, and in the semiconductor industry for its use in certain electronic components.

When handling 7-Chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials and disposed of in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.