2-(3,4-Difluorophenyl)cyclopropanamine(CAS: 633312-86-4)

2-(3,4-Difluorophenyl)cyclopropanamine is a colorless to white crystalline solid with a molecular weight of approximately 185.09 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like methanol and ethanol. The compound is moderately reactive, particularly towards nucleophiles and bases, making it susceptible to hydrolysis under basic conditions.

2-(3,4-Difluorophenyl)cyclopropanamine can be synthesized via a multistep process involving the preparation of the 3,4-difluorophenyl ring and subsequent amination with a primary amine. Common synthetic routes include the use of protected 3,4-difluorophenyl derivatives followed by deprotection and amidation. The reaction typically proceeds with high selectivity and good yield under mild conditions.

2-(3,4-Difluorophenyl)cyclopropanamine is primarily used in the pharmaceutical industry for the development of novel drug candidates due to its unique chemical structure. It also finds applications in the polymer industry for the synthesis of advanced materials and in the sensor and semiconductor sectors for specialized functional coatings and devices.

When handling 2-(3,4-Difluorophenyl)cyclopropanamine, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be immediately cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.