Methyl 1-methyl-5-oxo-D-prolinate(CAS: 122742-14-7)

Methyl 1-methyl-5-oxo-D-prolinate is a colorless crystalline solid with a molecular weight of approximately 168.22 g/mol. It has a faint, characteristic odor and is soluble in organic solvents like ethanol and acetone, but less so in water. This compound is reactive towards nucleophiles and can undergo various chemical transformations, making it useful in organic synthesis.

Methyl 1-methyl-5-oxo-D-prolinate can be synthesized by the condensation of 1-methyl-5-oxo-D-proline with methyl acetoacetate in the presence of an acid catalyst. The reaction is selective and yields up to 90% of the desired product, making it a valuable intermediate in the synthesis of D-proline derivatives.

Methyl 1-methyl-5-oxo-D-prolinate is primarily used in the pharmaceutical industry for synthesizing D-proline and related compounds. It is also utilized in the production of polymers and in the development of sensors and semiconductors, where its unique chemical properties make it a valuable component.

When handling Methyl 1-methyl-5-oxo-D-prolinate, it is essential to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.