2-Chloro-5-(trifluoromethyl)benzaldehyde(CAS: 82386-89-8)

2-Chloro-5-(trifluoromethyl)benzaldehyde (CAS: 82386-89-8) is a crystalline solid with a molecular weight of approximately 260.03 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is known for its high reactivity, particularly towards nucleophiles and electrophiles. It exhibits good stability under normal conditions but can react with bases to form an alkoxide.

2-Chloro-5-(trifluoromethyl)benzaldehyde (CAS: 82386-89-8) is commonly synthesized via the Friedel-Crafts alkylation of 2-chlorobenzaldehyde with trichloromethyl trifluoromethylsulfonate (triflate) in the presence of aluminum chloride as a catalyst. The reaction typically provides good yields and high selectivity, though careful control of reaction conditions is necessary to minimize side products.

2-Chloro-5-(trifluoromethyl)benzaldehyde (CAS: 82386-89-8) is utilized in various industries, including pharmaceuticals, where it serves as a precursor for synthesizing antiviral drugs. It is also used in the production of polymer additives and as a reagent in the development of sensors and semiconductors.

Proper handling of 2-Chloro-5-(trifluoromethyl)benzaldehyde (CAS: 82386-89-8) requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, it is advisable to use appropriate absorbent materials and refer to the Safety Data Sheet (SDS) for detailed instructions.