1-ethylpiperidine-4-carboxylic acid(CAS: 90204-94-7)

1-Ethylpiperidine-4-carboxylic acid (CAS: 90204-94-7) is a crystalline solid with a molecular weight of approximately 191.26 g/mol. It has a pKa of around 4.3 and is slightly soluble in water. The compound shows moderate reactivity with nucleophiles and bases. It is prone to hydrolysis under acidic conditions and can undergo amide coupling reactions.

1-Ethylpiperidine-4-carboxylic acid (CAS: 90204-94-7) can be synthesized by the amidation of 4-hydroxypiperidine with ethyl chloroformate in the presence of a phase-transfer catalyst. The reaction is carried out in an organic solvent like toluene at elevated temperature, typically around 60-80°C, with good yield (over 90%).

1-Ethylpiperidine-4-carboxylic acid (CAS: 90204-94-7) is primarily used in the pharmaceutical and polymer industries for the synthesis of various drugs and polymer precursors. It is also used in the production of organic sensors and as a reagent in organic chemistry research.

When handling 1-ethylpiperidine-4-carboxylic acid (CAS: 90204-94-7), it is essential to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work in a well-ventilated area or a fume hood. Store the compound in a cool, dry place away from oxidizing agents. In case of a spill, immediately clean up using appropriate absorbent materials and follow the safety data sheet (SDS) for further instructions.