5-Bromo-1,3-dimethyl-2-pyridone(CAS: 51417-13-1)

5-Bromo-1,3-dimethyl-2-pyridone is a crystalline solid with a molecular weight of approximately 228.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It decomposes above 200°C and is stable under acidic and basic conditions.

5-Bromo-1,3-dimethyl-2-pyridone is commonly synthesized via the bromination of 1,3-dimethyl-2-pyridone with N-bromosuccinimide (NBS) in the presence of a radical initiator like azobisisobutyronitrile (AIBN). The reaction is carried out at room temperature, and the yield is typically around 70-80%. The product is purified by recrystallization.

5-Bromo-1,3-dimethyl-2-pyridone is used in the pharmaceutical industry for the synthesis of certain drugs, particularly in the development of antifungal and antibacterial agents. It is also employed in the polymer industry for the modification of materials and in the electronics industry for the production of semiconductors and sensors.

When handling 5-Bromo-1,3-dimethyl-2-pyridone, it is recommended to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or within a fume hood to avoid inhalation of bromine fumes. Spills should be cleaned up using appropriate absorbent materials, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for more detailed information on handling and storage.