4-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one(CAS: 870552-47-9)

4-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one has a crystalline form with a molecular weight of approximately 268.04 g/mol. It is moderately soluble in common organic solvents like DMSO and acetone but poorly soluble in water. The compound exhibits moderate reactivity, particularly towards nucleophiles due to its electron-withdrawing bromine atom and electron-donating methyl groups.

4-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one is typically synthesized via a multi-step process starting from indole. The key steps include bromination of the indole ring, followed by acylation and methylation. The reaction is often catalyzed by Lewis acids and proceeds with good yield and selectivity.

4-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one is primarily used in the pharmaceutical industry for the synthesis of novel compounds with potential bioactivity. It is also utilized in the polymer industry for the development of advanced materials and in the field of chemical sensors for detecting specific compounds.

Proper personal protective equipment (PPE) should be worn when handling 4-Bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbent materials and discarded according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.