2-Iodo-3-(trifluoromethyl)pyridine(CAS: 927434-20-6)

2-Iodo-3-(trifluoromethyl)pyridine (CAS: 927434-20-6) is a crystalline solid with a molecular weight of approximately 267.04 g/mol. It has a low solubility in water but is soluble in organic solvents like methylene chloride and acetonitrile. It exhibits limited reactivity in neutral and basic conditions, making it suitable for various synthetic applications. It is stable under normal conditions but should be handled with care due to its chemical nature.

2-Iodo-3-(trifluoromethyl)pyridine (CAS: 927434-20-6) is typically synthesized through a Friedel-Crafts alkylation reaction of 3-(trifluoromethyl)pyridine with iodine in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction proceeds at a moderate temperature, yielding a high selectivity and yield of the desired product.

2-Iodo-3-(trifluoromethyl)pyridine (CAS: 927434-20-6) finds applications in pharmaceuticals, where it is used as an intermediate in the synthesis of drug candidates. It is also utilized in the development of new materials, including polymers and sensors, due to its unique chemical properties and reactivity.

When handling 2-Iodo-3-(trifluoromethyl)pyridine (CAS: 927434-20-6), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spillage, gloves should be used to clean up the area, and the spill should be handled according to the Material Safety Data Sheet (SDS). Always use a fume hood when performing operations with this compound to minimize exposure.