1-(beta-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione(CAS: 605-23-2)

1-(beta-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (CAS: 605-23-2) is a crystalline solid with a molecular weight of approximately 265.21 g/mol. It is slightly soluble in water. This compound is relatively stable under normal conditions but can react with strong acids or bases. It has a melting point of around 250-255°C and is a potent antiviral agent with significant biological activity.

1-(beta-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (CAS: 605-23-2) is synthesized through a multistep process involving condensation reactions, amidation, and selective alkylation. Common methods include the alkylation of 5-methyl-2,4(1H,3H)-pyrimidinedione with beta-D-arabinofuranosyl chloride in the presence of a base such as triethylamine. The overall yield is around 70-80%, with a high degree of selectivity towards the desired product.

1-(beta-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (CAS: 605-23-2) is primarily used in the pharmaceutical industry, where it serves as a key antiviral agent against herpes simplex virus and influenza. It is also of interest in academic research for its antimicrobial and antiparasitic properties, and in the development of new drug candidates. Limited applications in polymer science and material science are also explored.

When handling 1-(beta-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (CAS: 605-23-2), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Ensure that all operations are conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.