4-Bromo-6-chloropyridazin-3(2H)-one(CAS: 933041-13-5)

4-Bromo-6-chloropyridazin-3(2H)-one is a crystalline solid with a molecular weight of approximately 233.03 g/mol. It has a high melting point of around 250°C and is slightly soluble in water. The compound is known for its reactivity, particularly towards nucleophilic substitution reactions. It is a potent electrophile in organic synthesis, facilitating various functional group transformations.

4-Bromo-6-chloropyridazin-3(2H)-one is synthesized through a two-step process involving the bromination of 6-chloropyridazin-3(2H)-one followed by further modification. Commonly, this is achieved using N-bromosuccinimide (NBS) as a brominating agent in the presence of a radical initiator like AIBN. The reaction is carried out in an inert solvent such as dichloromethane (DCM) under UV light or heat, with high selectivity and good yield.

4-Bromo-6-chloropyridazin-3(2H)-one is used primarily in the pharmaceutical industry for the development of novel drugs. It also finds applications in the synthesis of polymers, where it can serve as a monomer or intermediate. Additionally, it is used in the production of sensors and semiconductors due to its unique electronic properties.

When handling 4-Bromo-6-chloropyridazin-3(2H)-one, appropriate personal protective equipment (PPE) is essential, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be managed carefully using appropriate absorbent materials. The material safety data sheet (MSDS) or safety data sheet (SDS) should be consulted for detailed safety information and emergency procedures.