Methyl 4-chloro-2-methoxynicotinate(CAS: 1256826-55-7)

Methyl 4-chloro-2-methoxynicotinate (CAS: 1256826-55-7) is a crystalline compound with a molecular weight of approximately 249.6 g/mol. It has a melting point of around 115-117°C and is slightly soluble in water. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is also susceptible to hydrolysis under basic conditions.

Methyl 4-chloro-2-methoxynicotinate (CAS: 1256826-55-7) is typically synthesized via the chlorination of 2-methoxynicotinic acid. The reaction is catalyzed by thionyl chloride (SOCl2) and proceeds with high yield and good selectivity. The process usually involves heating the mixture to around 80°C for a few hours.

Methyl 4-chloro-2-methoxynicotinate (CAS: 1256826-55-7) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the agricultural sector as a starting material for herbicides. Additionally, it has applications in the chemical industry for the production of other compounds and in research and development activities.

When handling Methyl 4-chloro-2-methoxynicotinate (CAS: 1256826-55-7), it is essential to wear appropriate Personal Protective Equipment (PPE), including gloves, goggles, and a laboratory coat. Use a fume hood during operations to minimize exposure to vapors. Spills should be handled with caution using appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage guidelines.