1-Methyl-2-pyrrolidinone-d9(CAS: 185964-60-7)

1-Methyl-2-pyrrolidinone-d9 is a colorless, odorless, and hygroscopic liquid at room temperature. It has a molecular weight of 130.19 g/mol and is highly soluble in water and organic solvents. This compound is stable under normal conditions but can react with strong acids and bases. It is commonly used as a solvent in chemistry and as a reference compound in NMR spectroscopy.

1-Methyl-2-pyrrolidinone-d9 is typically synthesized by the amination of 1-methyl-2-pyrrolidone. This process often involves the reaction of 1-methyl-2-pyrrolidone with methylamine in the presence of a suitable catalyst. The method is known for its good yield and selectivity, making it a reliable route for industrial production.

1-Methyl-2-pyrrolidinone-d9 is widely used in the pharmaceutical industry for the synthesis of APIs and drug intermediates. It is also utilized in the polymer industry as a solvent for polymers and in the semiconductor industry as a chemical mechanical polishing (CMP) slurry component. Additionally, it serves as a reference compound in NMR spectroscopy and as a reagent in analytical chemistry.

When handling 1-Methyl-2-pyrrolidinone-d9, it is essential to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed instructions and emergency procedures.