1,1,7,7-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde(CAS: 216978-79-9)

1,1,7,7-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde has a crystalline form, with a molecular weight of approximately 304.36 g/mol. It is poorly soluble in water but soluble in organic solvents such as methanol and dichloromethane. Chemically, it is moderately reactive, particularly towards nucleophiles. It can undergo Michael addition and condensation reactions.

1,1,7,7-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde is typically synthesized via a multistep process starting from 1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline. The key steps involve palladium-catalyzed cross-coupling reactions, followed by acylation. The reaction conditions include the use of palladium(II) acetate and triphenylphosphine as catalysts, with high selectivity and moderate yield.

1,1,7,7-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde is used in the pharmaceutical industry for the synthesis of bioactive compounds. It also finds applications in the field of organic electronics, specifically in the development of organic semiconductors and organic light-emitting diodes (OLEDs).

When handling 1,1,7,7-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using absorbent materials and discarded according to proper waste management protocols. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS).