(3S)-Tetrahydro-3-furancarboxylic acid(CAS: 168395-26-4)

(3S)-Tetrahydro-3-furancarboxylic acid is a colorless to white crystalline solid with a molecular weight of approximately 132.11 g/mol. It has a pKa value of around 4.7, indicating it is a weak acid. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. It is reactive towards bases and can undergo esterification and other acid-base reactions.

(3S)-Tetrahydro-3-furancarboxylic acid can be synthesized through the reduction of 3-furancarboxaldehyde with a suitable reducing agent such as sodium borohydride or lithium aluminum hydride. The reaction is typically carried out in an inert solvent like ethanol or diethyl ether. The yield is usually good, and the reaction can be optimized for selectivity and purity.

(3S)-Tetrahydro-3-furancarboxylic acid is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and as a precursor in the production of polymers and organic semiconductors. It also finds applications in the development of sensors and as a chiral building block in asymmetric synthesis.

When handling (3S)-Tetrahydro-3-furancarboxylic acid, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.