6-Phenyl-3(2H)-pyridazinone(CAS: 2166-31-6)

6-Phenyl-3(2H)-pyridazinone has a crystalline form with a molecular weight of approximately 195.19 g/mol. It is slightly soluble in water and is non-volatile. The compound is relatively stable, but it can undergo hydrolysis under basic conditions. It has a pKa of about 4.5, indicating some acidity.

6-Phenyl-3(2H)-pyridazinone is commonly synthesized by the condensation of 2-chloro-3-phenylpyridine with hydrazine hydrate. The reaction occurs in an aqueous medium at room temperature, with a yield of around 80%. The process is catalyzed by a small amount of sodium hydroxide to facilitate the reaction.

6-Phenyl-3(2H)-pyridazinone is primarily used in the pharmaceutical industry for its potential as a drug intermediate. It also finds applications in the synthesis of organic polymers, where it serves as a monomer or a cross-linking agent. Additionally, it is utilized in the development of sensors and semiconductors due to its unique electronic properties.

When handling 6-Phenyl-3(2H)-pyridazinone, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct light and heat. Inhalation and skin contact should be avoided; in case of spillage, use a fume hood and consult the safety data sheet (SDS) for proper disposal procedures.