2-Bromo-5-chloroisonicotinic acid(CAS: 530156-90-2)

2-Bromo-5-chloroisonicotinic acid is a crystalline solid with a molecular weight of approximately 241.03 g/mol. It has a low solubility in water (0.1 g/L at 20°C) and moderate solubility in organic solvents. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from moisture and strong acids.

2-Bromo-5-chloroisonicotinic acid is typically synthesized via electrophilic aromatic substitution reactions. Common methods include the bromination and chlorination of nicotinic acid followed by condensation reactions. The synthesis often involves the use of bromine and chlorine as electrophiles, with acetic anhydride as a condensing agent. The yield is around 70-80% depending on the purity of starting materials and reaction conditions.

2-Bromo-5-chloroisonicotinic acid is primarily used in pharmaceuticals for the synthesis of certain drug intermediates. It also has applications in the production of sensors and as a precursor in semiconductor manufacturing. Its use in polymers is limited due to its reactivity and specific functional groups.

When handling 2-Bromo-5-chloroisonicotinic acid, it is important to use appropriate Personal Protective Equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a fume hood to minimize exposure to vapor. In case of spill, immediately clean up with water and absorbent material. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures. Storage should be in a cool, dry place away from direct sunlight and strong acids.