2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one(CAS: 1449598-86-0)

2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one is a crystalline solid with a molecular weight of approximately 228.01 g/mol. It is slightly soluble in water and ethanol. Chemically, it is classified as a heterocyclic compound, exhibiting moderate to high reactivity, particularly with nucleophiles. It can engage in various reactions, such as nucleophilic substitution and condensation reactions.

2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one can be synthesized through the condensation reaction of 2-chloro-4H-pyrido[1,2-a]pyrimidin-4-one with a fluoro compound in the presence of a Lewis acid catalyst. Commonly used catalysts include aluminum chloride or zinc chloride. The reaction is typically carried out under mild conditions, with moderate to good yields.

2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one is primarily used in the pharmaceutical industry, particularly in the development of antiviral drugs. It may also find applications in the polymer industry for the synthesis of functionalized polymers with specific properties, and in the sensor industry for the fabrication of chemical sensors with high selectivity.

When handling 2-Chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).