4-Isobutylpyrrolidin-2-one(CAS: 61312-87-6)

4-Isobutylpyrrolidin-2-one is a colorless to pale yellow liquid with a strong odor. Its molecular weight is approximately 145.23 g/mol. It has a high solubility in organic solvents like ethanol and acetone but is insoluble in water. It is moderately reactive with weak nucleophiles and exhibits good stability under normal storage conditions. The compound is poorly soluble in water, making it suitable for applications requiring good solubility in organic media.

4-Isobutylpyrrolidin-2-one is commonly synthesized via a reaction between 2-chloro-4-isobutylpyrrole and potassium hydroxide in an aprotic solvent like dimethyl sulfoxide (DMSO). This method provides good yield and selectivity, with the reaction occurring under mild conditions. Other methods include the Wittig reaction involving isobutyl chlorophosphite and 2-pyrrolidonium bromide, which also yields high purity and selectivity.

4-Isobutylpyrrolidin-2-one is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the production of polymers as a monomer, in sensors for detecting specific chemical compounds, and in semiconductor manufacturing as a precursor for functional materials. Its versatile chemical properties make it suitable for a range of industrial processes.

When handling 4-Isobutylpyrrolidin-2-one, it is essential to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Ensure that the substance is stored in a cool, dry place away from direct sunlight and heat sources. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation of vapors. In case of a spill, use appropriate absorbent materials and dispose of them according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.