5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone(CAS: 706811-25-8)

5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone is a white solid with a crystalline form. Its molecular weight is approximately 314.03 g/mol. It is slightly soluble in water and has good solubility in organic solvents. This compound is known for its reactivity, particularly towards nucleophilic substitution and condensation reactions.

5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone can be synthesized via a multi-step process involving bromination of a phenyl group, followed by reaction with pyrimidine. Commonly used reagents include bromine and a Lewis acid catalyst such as aluminum bromide. The reaction typically yields a high purity product with good selectivity and moderate to high yield.

5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone finds applications in pharmaceuticals, where it is used as an intermediate in the synthesis of medicinal compounds. It is also utilized in the polymer industry for functionalization purposes and in the manufacturing of advanced materials. Its use in sensors and semiconductors is also being explored due to its unique chemical properties.

When handling 5-(4-Bromophenyl)-6-hydroxy-4(1H)-pyrimidinone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling information and emergency procedures.