2-(Dimethylamino)-4-pyrimidinecarbaldehyde(CAS: 872707-78-3)

2-(Dimethylamino)-4-pyrimidinecarbaldehyde is a white crystalline solid with a molecular weight of approximately 210.21 g/mol. It has poor water solubility but is soluble in organic solvents. This compound is known for its reactivity towards nucleophiles and its ability to form Schiff bases. It exhibits moderate stability under normal conditions but can undergo hydrolysis under acidic or basic conditions.

2-(Dimethylamino)-4-pyrimidinecarbaldehyde can be synthesized through the condensation of 4-cyanopyrimidine with dimethylamine followed by oxidation. The reaction is typically performed under mild conditions using a suitable oxidant like potassium permanganate or sodium hypochlorite. The yield is generally around 70-80%, and the reaction proceeds with high selectivity to the desired product.

2-(Dimethylamino)-4-pyrimidinecarbaldehyde is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the polymer industry as a coupling agent and in the production of sensors and semiconductors due to its unique chemical properties.

When handling 2-(Dimethylamino)-4-pyrimidinecarbaldehyde, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.