(2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid(CAS: 324519-66-6)

(2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid is a white crystalline solid with a molecular weight of 199.61 g/mol. It is slightly soluble in water and has a pKa of around 3.9. The compound is chemically reactive, particularly towards nucleophiles and bases, and is prone to hydrolysis under basic conditions.

(2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid is typically synthesized via a multi-step process involving the epoxidation of a terminal alkene followed by ring-opening with hydrochloric acid. The reaction is carried out in a solvent such as dichloromethane, with a suitable catalyst to promote the reaction selectively.

(2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It may also find applications in the polymer industry for the modification of polymers and in the development of sensors and semiconductors.

When handling (2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work within a fume hood to minimize exposure. Spills should be cleaned up with caution using absorbent materials and appropriate chemical spill kits. Always consult the material safety data sheet (MSDS) for detailed safety information.