5-Methyl-1,2-oxazole-3-carbonyl chloride(CAS: 39499-34-8)

5-Methyl-1,2-oxazole-3-carbonyl chloride is a white crystalline solid with a molecular weight of 150.03 g/mol. It has a slight pungent odor and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it reacts readily with nucleophiles and is an electrophilic reagent in condensation reactions.

5-Methyl-1,2-oxazole-3-carbonyl chloride is typically synthesized by reacting 5-methyl-1,2-oxazole with thionyl chloride. The reaction yields a white solid with high selectivity and a good yield, making it a reliable method for industrial production.

5-Methyl-1,2-oxazole-3-carbonyl chloride is commonly used in pharmaceuticals for the synthesis of various drugs, as a precursor in polymer chemistry for creating functional materials, and in sensor technologies due to its reactivity with amines.

When handling 5-Methyl-1,2-oxazole-3-carbonyl chloride, use personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation. Store in a cool, dry place away from heat and oxidizers. In case of a spill, neutralize with an appropriate base and dispose of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.