8-Fluoro-3-quinolinecarboxylic acid(CAS: 71082-53-6)

8-Fluoro-3-quinolinecarboxylic acid (CAS: 71082-53-6) is a crystalline solid with a molecular weight of approximately 210.14 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is reactive towards bases and can undergo ring-opening reactions. It has a pKa of about 2.8, indicating it is a weak acid.

8-Fluoro-3-quinolinecarboxylic acid (CAS: 71082-53-6) is typically synthesized through the condensation of 3-aminoquinoline with a fluoroacyl halide in the presence of a base like sodium hydride. The reaction selectively forms the desired product with good yield. The use of a suitable catalyst can improve the reaction selectivity and efficiency.

8-Fluoro-3-quinolinecarboxylic acid (CAS: 71082-53-6) is primarily used in the pharmaceutical industry for the synthesis of various bioactive molecules. It also finds applications in the polymer industry as a functional monomer, in the development of sensors due to its fluorescence properties, and in semiconductor manufacturing processes for its electronic properties.

When handling 8-Fluoro-3-quinolinecarboxylic acid (CAS: 71082-53-6), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its reactivity. In case of a spill, it should be cleaned up using appropriate absorbent materials. Refer to the Material Safety Data Sheet (MSDS/SDS) for detailed handling instructions and emergency procedures.