2,4-Hexadienoic acid(CAS: 22500-92-1)

2,4-Hexadienoic acid is a colorless or white solid with a melting point of 53-54°C. Its molecular weight is approximately 134.14 g/mol. It has a pKa of 4.8 and is slightly soluble in water. The compound exhibits esterification and amide formation reactions. It is prone to oxidation and polymerization under certain conditions.

2,4-Hexadienoic acid can be synthesized via the hydrolysis of 2,4-hexadienoyl chloride or through the malonic ester synthesis route. Common catalysts include sulfuric acid or hydrochloric acid. The reaction typically yields a high percentage of the desired product with good selectivity.

2,4-Hexadienoic acid is used in the pharmaceutical industry as a precursor to various drug molecules. It is also utilized in the polymer industry for the synthesis of polyesters and in the sensor industry for developing gas sensors. Additionally, it finds applications in the semiconductor industry for modifying surfaces.

When handling 2,4-hexadienoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a cool, dry place away from direct sunlight and moisture. In case of a spill, use appropriate spill containment and clean-up procedures. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.