Methyl 3-bromo-2H-indazole-6-carboxylate(CAS: 192945-56-5)

Methyl 3-bromo-2H-indazole-6-carboxylate (CAS: 192945-56-5) is a crystalline solid with a molecular weight of approximately 270.03 g/mol. It is slightly soluble in water and has good solubility in common organic solvents like dichloromethane and acetonitrile. Chemically, it is a reactive compound, which can undergo substitution reactions at the bromine atom. It is also prone to hydrolysis in the presence of moisture.

Methyl 3-bromo-2H-indazole-6-carboxylate (CAS: 192945-56-5) is commonly synthesized via the bromination of methyl 2H-indazole-6-carboxylate using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction proceeds with high selectivity and good yield, typically around 75-85%.

Methyl 3-bromo-2H-indazole-6-carboxylate (CAS: 192945-56-5) is used in the pharmaceutical industry for the synthesis of various indazole-based drugs due to its potential biological activity. It also finds applications in the polymer industry for the development of new materials and in the semiconductor industry for use in organic electronics.

When handling Methyl 3-bromo-2H-indazole-6-carboxylate (CAS: 192945-56-5), it is crucial to work in a well-ventilated environment and use a fume hood. Wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Spills should be cleaned up promptly with appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.