N-Tosyl-L-alanine(CAS: 21957-58-4)

N-Tosyl-L-alanine (CAS: 21957-58-4) is a white crystalline solid with a molecular weight of approximately 248.19 g/mol. It is sparingly soluble in water and ethanol. This compound is reactive towards hydrolysis and has a pKa of about 2.8, making it acidic. It can be used as a racemizing agent in organic synthesis and as a building block in peptide chemistry.

N-Tosyl-L-alanine (CAS: 21957-58-4) is synthesized via the tosylation of L-alanine using para-toluenesulfonyl chloride (pTsCl) as the reagent. The reaction is typically carried out in the presence of a base such as pyridine. The yield is usually around 90%, and the product can be isolated by recrystallization from an appropriate solvent.

N-Tosyl-L-alanine (CAS: 21957-58-4) is primarily used in the pharmaceutical industry as a racemizing agent and in the synthesis of peptides. It is also utilized in the polymer industry for the preparation of monomers and in the semiconductor industry for the synthesis of various materials used in device fabrication.

When handling N-Tosyl-L-alanine (CAS: 21957-58-4), it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using an appropriate absorbent material and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.