3-(4-pyridyl)prop-2-enoic acid(CAS: 5337-79-1)

3-(4-pyridyl)prop-2-enoic acid is a crystalline solid with a molecular weight of approximately 183.17 g/mol. It has a solubility of 0.2 g/100 mL in water and a pKa of 3.4. The compound exhibits moderate reactivity, particularly in acidic conditions, and is susceptible to hydrolysis and oxidation.

3-(4-pyridyl)prop-2-enoic acid is commonly synthesized via the reaction of 4-pyridylprop-2-yl acetoacetate with hydrochloric acid in an acidic medium under heating. The process is known for its good yield and selectivity, though careful control of reaction conditions is necessary to avoid side reactions.

3-(4-pyridyl)prop-2-enoic acid is widely utilized in pharmaceuticals for the synthesis of intermediates and raw materials, as well as in the production of sensors and semiconductors for electronics. Its applications in polymer chemistry and materials science are also growing due to its unique reactivity and functional groups.

When handling 3-(4-pyridyl)prop-2-enoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a tightly sealed container in a cool, dry place away from direct sunlight and heat sources. In case of spillage, the area should be ventilated, and the spill should be cleaned up using appropriate methods as per the safety data sheet (SDS).