2-Phenylpiperidin-4-one hydrochloride(CAS: 1245648-13-8)

2-Phenylpiperidin-4-one hydrochloride is a white crystalline solid with a molecular weight of approximately 265.68 g/mol. It is soluble in water and ethanol. The compound is relatively stable but can react with bases. Its solubility in water is 10 g/L at 25°C.

2-Phenylpiperidin-4-one hydrochloride can be synthesized by the condensation of piperidine-4-one with phenyl isocyanate, followed by hydrochlorination. The reaction typically yields 90% purity with good selectivity, and common catalysts include triethylamine and dichloromethane.

2-Phenylpiperidin-4-one hydrochloride is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It also finds applications in the polymer industry for the modification of polymer properties and in the sensor industry for use as a chromogenic reagent.

When handling 2-Phenylpiperidin-4-one hydrochloride, it is important to use personal protective equipment such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling information.