8-Bromo-3,4-dihydro-2(1H)-quinolinone(CAS: 67805-68-9)

8-Bromo-3,4-dihydro-2(1H)-quinolinone is a white crystalline solid with a molecular weight of approximately 227.09 g/mol. It has a solubility of about 8 mg/mL in water and 220 mg/mL in ethanol. The compound is moderately reactive, particularly towards nucleophilic substitution at the bromine atom. It is stable under normal storage conditions but can decompose upon heating.

8-Bromo-3,4-dihydro-2(1H)-quinolinone can be synthesized via a bromination reaction of 3,4-dihydro-2(1H)-quinolinone with N-bromosuccinimide (NBS) in the presence of a radical initiator like azobisisobutyronitrile (AIBN). The reaction yields 8-bromo-3,4-dihydro-2(1H)-quinolinone with good selectivity and moderate yield.

8-Bromo-3,4-dihydro-2(1H)-quinolinone is used in the pharmaceutical industry for the synthesis of certain drug intermediates and as a research compound for developing new drugs. It is also utilized in the polymer industry for the modification of polymer properties and in sensor technology for its unique reactivity.

When handling 8-Bromo-3,4-dihydro-2(1H)-quinolinone, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Handle in a well-ventilated area or fume hood to avoid inhalation of vapors. Store in a cool, dry place away from heat and direct sunlight. In case of spill, immediately contain and clean up using appropriate absorbent materials, and dispose of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.