(2S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine(CAS: 848821-61-4)

(2S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine has a crystalline form and a molecular weight of approximately 685.34 g/mol. It is poorly soluble in water but soluble in common organic solvents. Reactivity is moderate, with potential for nucleophilic substitution. It exhibits good thermal stability and is non-flammable.

(2S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine is synthesized through a multistep process involving protection of the pyrrolidine nitrogen, formation of the bis[3,5-bis(trifluoromethyl)phenyl] ether intermediate, and subsequent deprotection. Commonly used catalysts include trifluoromethanesulfonic acid, and the overall yield is typically around 70%. The reaction is conducted under an inert atmosphere to prevent decomposition.

(2S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds. It is also utilized in polymer science for the development of novel materials and in sensor technology for detecting specific chemical species. Its unique chemical structure makes it a valuable reagent in various academic and industrial research.

When handling (2S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.