5-Bromo-4-ethoxy-1H-indazole(CAS: 850363-68-7)

5-Bromo-4-ethoxy-1H-indazole is a white to off-white crystalline solid with a molecular weight of approximately 266.17 g/mol. It has a moderate solubility in common organic solvents like ethanol and acetone. Chemically, it is fairly stable but can react with strong bases and reducing agents. Its reactivity is mainly observed in halogenation and alkylation reactions.

5-Bromo-4-ethoxy-1H-indazole is typically synthesized via a bromination reaction of 4-ethoxy-1H-indazole using bromine in the presence of a base like sodium hydroxide. The reaction is carried out in a solvent such as acetic acid, yielding a mixture of products which can be purified by recrystallization or column chromatography.

5-Bromo-4-ethoxy-1H-indazole is used in the pharmaceutical industry for the synthesis of certain biologically active compounds. It is also relevant in the sensor industry for developing gas sensors and in semiconductor technology for doping applications.

When handling 5-Bromo-4-ethoxy-1H-indazole, proper personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat is essential. It should be stored in a well-ventilated area, preferably in a fume hood. Spills should be handled with care, using appropriate absorbent materials, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.