O-[2-(Diethylamino)-6-methyl-4-pyrimidinyl] O,O-diethyl phosphorothioate(CAS: 23505-41-1)

O-[2-(Diethylamino)-6-methyl-4-pyrimidinyl] O,O-diethyl phosphorothioate is a crystalline compound with a molecular weight of approximately 418.5 g/mol. It has a low water solubility but is soluble in organic solvents like acetonitrile. It is moderately reactive, showing some hydrolytic stability but being susceptible to nucleophilic substitution reactions. It has a melting point of around 150-152°C and is stable under normal laboratory conditions.

O-[2-(Diethylamino)-6-methyl-4-pyrimidinyl] O,O-diethyl phosphorothioate is synthesized via a multi-step procedure that involves the condensation of 2-(diethylamino)-6-methyl-4-pyrimidinyl chloride with diethyl phosphite in the presence of a base like triethylamine. The reaction is typically carried out in anhydrous organic solvents at room temperature. The yield is around 85%, and the product is purified using column chromatography.

O-[2-(Diethylamino)-6-methyl-4-pyrimidinyl] O,O-diethyl phosphorothioate is used in the pharmaceutical industry for its potential as an antifungal agent. It is also explored for its applications in sensors for detecting various chemicals, and it may have potential uses in the field of semiconductors and materials science due to its unique chemical properties.

When handling O-[2-(Diethylamino)-6-methyl-4-pyrimidinyl] O,O-diethyl phosphorothioate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a fume hood to minimize inhalation risk. Proper spill management procedures should be followed, and in case of skin contact, the affected area should be washed with soap and water immediately. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.