(3S)-1,3,4-Trihydroxy-2-butanone(CAS: 533-50-6)

The compound (3S)-1,3,4-Trihydroxy-2-butanone has a crystalline form and a molecular weight of 154.14 g/mol. It is sparingly soluble in water but miscible with ethanol and acetone. Chemically, it is highly reactive, particularly with reducing agents and nucleophiles. It exhibits reducing properties and can undergo oxidation and esterification reactions.

(3S)-1,3,4-Trihydroxy-2-butanone can be synthesized via the reduction of 2,3,4-trihydroxybutanone. Commonly, this is achieved using lithium aluminum hydride (LAH) as a reducing agent, followed by acid workup. The reaction yield is typically around 70-80%, with LAH serving as a key catalyst in this process.

(3S)-1,3,4-Trihydroxy-2-butanone finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also used in the polymer industry as a precursor for the production of biodegradable plastics. Additionally, it plays a role in sensor technology and as a chemical reagent in analytical chemistry.

When handling (3S)-1,3,4-Trihydroxy-2-butanone, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be neutralized with a suitable base, and the area should be thoroughly cleaned. Safety data sheets (SDS) should be consulted for detailed handling and disposal information.