2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS: 610768-32-6)

2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a solid, crystalline compound with a molecular weight of approximately 362.43 g/mol. It has low water solubility and moderate solubility in organic solvents like DMF and DMSO. This compound shows high reactivity in boron-containing reactions, such as cross-coupling reactions. It is stable under normal conditions but should be handled in a fume hood to avoid inhalation and contact with skin.

2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine can be synthesized through a palladium-catalyzed coupling reaction. The synthesis involves the reaction of 2-methylpyridine with 4,4,5,5-tetramethyl-2-borabicyclo[2.2.1]heptane in the presence of a palladium catalyst and a base. The reaction yields a high selectivity and good yield, making it a useful intermediate for organic synthesis.

2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is primarily used in the pharmaceutical and polymer industries. It serves as an important intermediate in the synthesis of drugs and polymers. Additionally, it finds applications in sensors and materials science for its unique chemical properties.

When handling 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up using appropriate absorbents and disposed of according to safety guidelines. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.