1-(3-Hydroxy-4-methoxyphenyl)ethanone(CAS: 6100-74-9)

1-(3-Hydroxy-4-methoxyphenyl)ethanone has a crystalline form and a molecular weight of approximately 214.22 g/mol. It is slightly soluble in water and has good solubility in organic solvents such as ethanol and dichloromethane. The compound is moderately reactive, showing partial acidity due to the hydroxyl group and partial basicity due to the methoxy group. It exhibits a melting point of 87-88°C and a boiling point of 225-227°C. It is a colorless to slightly yellow liquid at room temperature.

1-(3-Hydroxy-4-methoxyphenyl)ethanone is typically synthesized via a condensation reaction between 3-hydroxy-4-methoxybenzaldehyde and acetaldehyde. The reaction is catalyzed by acid catalysts such as p-toluenesulfonic acid (p-TSA) and proceeds with a yield of about 70-80%. The process involves heating the mixture under reflux conditions for several hours, followed by purification using column chromatography or crystallization techniques.

1-(3-Hydroxy-4-methoxyphenyl)ethanone is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also utilized in the production of polymers, where it acts as a monomer. Additionally, it finds applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1-(3-Hydroxy-4-methoxyphenyl)ethanone (CAS: 6100-74-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be stored in a well-ventilated area and away from sources of ignition. In case of a spill, the area should be ventilated and the spill cleaned up using absorbent materials. Consult the Safety Data Sheet (SDS) for detailed information and emergency procedures.