(S)-Tenofovir(CAS: 147127-19-3)

(S)-Tenofovir is a white to off-white crystalline powder with a molecular weight of approximately 354.31 g/mol. It has a melting point of around 180-183°C and is poorly soluble in water but soluble in organic solvents like methanol and ethanol. It is stable in acidic and neutral media but reacts with strong bases. (S)-Tenofovir is an antiviral drug used in the treatment of HIV and hepatitis B.

(S)-Tenofovir is synthesized through a stereoselective synthesis involving cyclization and reduction of a specific tetrahydrofuran derivative. The process employs a chiral auxiliary to achieve the (S)-configuration. The overall yield is moderate, and the method is known for its high stereoselectivity. Catalysts used include transition metal complexes and chiral ligands.

(S)-Tenofovir is primarily used in the pharmaceutical industry for the treatment of HIV and hepatitis B. It has applications in the development of antiviral drugs and as an intermediate in the synthesis of related compounds. While not extensively used in other industries like polymers or semiconductors, its derivatives might be explored in these fields for specialized applications.

When handling (S)-Tenofovir, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. Work in a well-ventilated area or a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety guidelines.