(1,5-Dimethyl-1H-indazol-6-yl)boronic acid(CAS: 1310383-98-2)

The (1,5-Dimethyl-1H-indazol-6-yl)boronic acid has a crystalline form at room temperature. Its molecular weight is approximately 298.29 g/mol. It shows limited solubility in water, with a solubility of about 0.1 g/L. This compound is relatively stable under normal conditions but reacts with strong acids. It is used in organic synthesis, particularly in coupling reactions involving boronic acids.

The (1,5-Dimethyl-1H-indazol-6-yl)boronic acid is typically synthesized via a multistep process involving the preparation of 1,5-dimethylindazole followed by boronation. Common catalysts used in the synthesis include Pd(PPh3)4 and other palladium complexes. The yield can vary depending on the conditions, but it is generally around 70-80%.

The (1,5-Dimethyl-1H-indazol-6-yl)boronic acid is used primarily in the pharmaceutical industry, particularly in drug discovery and synthesis. It is also utilized in polymer chemistry and sensor technology for its boronic acid functionality, which facilitates specific interactions with sugars and other compounds.

When handling (1,5-Dimethyl-1H-indazol-6-yl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be used in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate methods, and the material safety data sheet (MSDS) should be consulted for specific handling and disposal guidelines.