Folinic acid calcium salt pentahydrate(CAS: 6035-45-6)

Folinic acid calcium salt pentahydrate is a white crystalline powder with a molecular weight of approximately 641.55 g/mol. It is sparingly soluble in water and has limited solubility in organic solvents. Chemically, it is a salt with good stability under neutral and slightly acidic conditions but can react with strong acids or bases. It is often used in pharmaceutical applications due to its stability and solubility characteristics.

Folinic acid calcium salt pentahydrate is typically synthesized by reacting 5-formyltetrahydrofolate with calcium chloride in an aqueous solution. This process involves careful control of pH and temperature to ensure high yield and selectivity. The reaction is usually carried out in a solution that is gradually cooled to precipitate the desired salt form.

Folinic acid calcium salt pentahydrate is primarily used in the pharmaceutical industry for the treatment of folate deficiency and certain types of anemia. It is also used in the food industry as a food fortifier and in the agricultural sector as a nutrient additive for livestock. Additionally, it has applications in research and diagnostics where its properties are utilized.

When handling Folinic acid calcium salt pentahydrate, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a dry, well-ventilated area away from strong acids and bases. In case of spills, use appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.