(4-Methyl-2-oxo-2H-chromen-7-yl)phosphonic acid(CAS: 3368-04-5)

(4-Methyl-2-oxo-2H-chromen-7-yl)phosphonic acid is a crystalline solid with a molecular weight of approximately 258.23 g/mol. It is slightly soluble in water and has a pKa of 2.55. This compound is reactive, particularly towards nucleophiles and bases, making it suitable for various chemical synthesis applications.

(4-Methyl-2-oxo-2H-chromen-7-yl)phosphonic acid can be synthesized through the reaction of 4-methyl-7-hydroxychromene with phosphorous acid. This process yields the desired product with good selectivity and a high yield of up to 90%. Suitable conditions include refluxing the reaction mixture in an organic solvent such as dichloromethane.

(4-Methyl-2-oxo-2H-chromen-7-yl)phosphonic acid finds applications in the pharmaceutical industry for the synthesis of intermediates, in polymer chemistry for functionalizing polymers, and in the production of sensors and semiconductors due to its unique chemical properties.

When handling (4-Methyl-2-oxo-2H-chromen-7-yl)phosphonic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, neutralize it with a base before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines.