3-Aminoisonicotinic acid hydrate (1:1)(CAS: 7529-20-6)

3-Aminoisonicotinic acid hydrate (1:1) is a crystalline solid with a molecular weight of approximately 181.17 g/mol. It has a solubility of about 10 g/L in water at 20°C. The compound is moderately reactive, particularly in acidic conditions. It is stable under normal laboratory conditions but may degrade under strongly basic conditions.

3-Aminoisonicotinic acid hydrate (1:1) is commonly synthesized by reacting nicotinic acid with primary amines in an aqueous medium. The reaction typically involves the use of ammonium hydroxide as a base, and the process yields a 1:1 hydrate with good selectivity. The yield is generally around 85-90%.

3-Aminoisonicotinic acid hydrate (1:1) is utilized in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving nicotinamide derivatives. It is also used in the polymer industry for the modification of polymer properties, and in the sensor industry for developing sensitive detection systems.

When handling 3-Aminoisonicotinic acid hydrate (1:1), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Storage should be in a cool, dry place, away from direct sunlight. In case of spills, use appropriate spill kits and ensure the area is well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling instructions.