1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone(CAS: 93265-81-7)

1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone (CAS: 93265-81-7) is a crystalline solid with a molecular weight of approximately 347.03 g/mol. It has limited water solubility and exhibits specific reactivity towards nucleophilic substitution at the iodine atom. This compound is stable under dry conditions but requires handling in an inert atmosphere to prevent moisture and air oxidation.

1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone is synthesized through a multi-step process involving the condensation of 2-iodo-5-pyrimidinone with 2-deoxy-D-erythronic acid under anhydrous conditions. The reaction typically employs a Lewis acid catalyst, such as aluminum trichloride, to promote the formation of the desired product with a yield of approximately 70-80%. The reaction is highly selective and can be optimized for better yield and purity.

1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone (CAS: 93265-81-7) is primarily used in the pharmaceutical industry for the development of antiviral drugs. It also finds applications in research related to nucleic acid chemistry and as an intermediate in the synthesis of other bioactive compounds. Its use in polymer and semiconductor industries is limited but continues to be explored for its unique properties.

When handling 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone (CAS: 93265-81-7), it is crucial to use personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. The compound should be stored in a cool, dry place away from moisture and heat sources. Spills should be cleaned up promptly using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.